Yutaka Manabe

Mimihara General Hospital, Sakai, Japan


Objective: As skin colonization with Staphylococcus aureus influences the disease process of atopic dermatitis (AD), recently Candida sp. colonizing in the intestinal tract reportedly play a role in the exacerbation of AD synptoms. We studied the clinical features of AD patients with intestinal colonization of Candida sp.

Methods: Among 550 patients with AD in our clinics, 15 patients with positive specific IgE to Candida and positive stool colonization of Candida sp. were selected. Clinical courses and synptoms and laboratory data were studied.

Results: 12 patients had specific IgE to food antigens, among them 7 to more than 5 food allergens. Serum IgE level above 10000 IU/ml was observed in 3 patients and others above 1000 IU/ml. Complications such as cataracta was observed in 3 patients.  History of severe AD was noticed in 11 patients, among those patients 8 had the episode of exervation late childhood. All patients had the history of positive skin colonization with Staphylococcus aureus. All were given disinfectant treatment on skin lesions with various compliance.10 were treated with oral nystatin and elimination diet. Good response was bserved in 6 patients with good compliance of both therapy.

Conclusion: As with Staphylococcal skin infection, AD patients with Candida allergy especially with intestinal colonization of Candida sp. have severe AD and high incidence of complications.