SUPPRESSIVE EFFECTS OF
HIGH DOSE IVIG ON FUNCTIONS OF T AND B LYMPHOCYTE OF NEONATES WITH
PNEUMONIA
Zhao
XD, Yang XQ & Luo. HQ
Children’s
Hospital, Chongqing University of Medical Sciences, Chongqing, China
Objective: To observe the therapeutic and immunosuppressive
effects of intravenous immunoglobulin (IVIG) in neonates with pneumonia.
Methods: Forty-one (fatus generation ranged from 36 to 41
weeks) neonates with pneumonia were randomly divided into 3 groups, with 20
neonates in control group, 15 neonates in group of lower dose IVIG in which
500-700mg/kg IVIG infused and 6 neonates in group of higher dose IVIG in
which 1000-1200mg/kg IVIG infused, respectively. IVIG was administered
during the 1st to 4th day of the disease onset. Serum
IgG, IgM, IgA and IgG subclasses, proliferation of T and B lymphocytes,
IL-2, Il-4 and IL-6 produced by PBMC in vitro, IgG subclass levels in PBMC
culture supernatants were detected by ELISA and 3H-TdR
incorporation assay respectively before and 2-4 days after IVIG treatment.
Results: There is no clinical differentiation in all neonates
with pneumonia to be observed. Serum IgG and IgG subclass levels in two
IVIG groups increased markedly. However, proliferation of T and B
lymphocyte, IL-2, IgG1, IgG2 and IgG3
production in higher dose IVIG group decreased significantly after IVIG
treatment compared with other groups.
Conclusion:
It’s unlikely that IVIG treatment in favor of neonatal pneumonia. Due to
its suppressive effects on functions of T and B lymphocytes at least in
short term, we advise that its uses in neonatal infections be decided by
the functional situation of neonate’s immune system and abusing of IVIG be
forbidden.