SHORT-TERM STOSSTHERAPY BY METHYLPREDISOLONE(MPSS) IN CHILD PATIENTS WITH SEVERE ASTHMA(AFFILIATED WITH ANALYSIS OF EIGHTEEN CASES)

Zhang R-Y

Children’s Hospital, Chongqing University of Medical Sciences, Chongqing, China

 

Objective: To study the outcome of short-term stosstherapy by mpss in child - patients with severe asthma.

Methods: All thirty-two patients who had severe asthma were selected in accordance with the diagnostic standard of asthma and randomly enrolled into two groups. In the mpss group (n=18), the dose of mpss was 2-4mg/kg, q8h also for three days, while in the control group(n=14), dexamethasone was administered intravenously with 0.5~0.75mg/kg, q8h also for three days. Other treatments were the same in two groups.

Results: After three-day treatment, in mpss group, there was a shorter time of duration of cough, wheezing and stridor than that in control group and the results of P were <0.01,<0.05 and <0.05, respectively. There were significantly better results in Pao2, Paco2, PH and PEFR (P<0.01). But in control group, no significant changes were found in Paco2, PH and PEFR except Pao2 with a few changes  (P>0.05) .

Conclusion: Asthmatic is a kind of allergic disease with inflammation in airway. Glucocorticoids is the most effective medication administered to diminish airway inflammation. The commonly-used glucocorticoids include dexamethasone, hydrocortisone and mpss. Our data demonstrates that mpss is better than dexamethasone in anti-inflammation and bronchochilation for child patients with severe asthma which is the best choice of glucocorticoids to treat severe asthma.

 

 
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