VARIATION IN SERUM MB ISOENZYME OF CREATINE
KINASE, CARDIAC TROPONIN I IN CHILDREN WITH VIRAL MYOCARDITIS
YI Qijian,QIAN Yongru, ZHANG Yumei, et
al.
Children’s Hospital, Chongqing University of
Medical Sciences, Chongqing, China
Objective: The aim of the study was
to investigate the mechanism of myocyte injury in children with viral
myocarditis（VMC）.
Methods: Serum MB isoenzyme of
creatine kinase（CK-MB）, cardiac troponin I（cTnI）, peripheral blood T lymphocyte subsets, B
lymphocyte, natural kill cell （NK）, enteroviral RNA（CBV-RNA）, coxsakivirus B specific antibody IgM（CBV-IgM）, lymphocyte proliferative index（PI）, complement 3（C3）, left ventricular
ejective fraction（LVEF）were detected in children
with VMC which were included 32 cases at acute stage of VMC,and 12 cases at
the procrastinate and chronic stage.
Results: In the 2 weeks stage of
VMC, the levels of serum CK-MB, cTnI increased significantly (p<0.002
and p<0.001, respectively), CD3,
CD4, CD8,, CD4/CD8, CD49,
CD56 cells, PI, C3 as same as control group, the
percentage of positive serum CBV-IgM, peripheral blood lymphocyte CBV-RNA
were higher in patient group than in control group （P>0.05
and P<0.05, respectively）, LVEF was decreased（P<0.05）; In the
course of 8 weeks of VMC, the levels of serum CK-MB, cTnI were increased
again, CD3, CD4, CD8, CD56,
LVEF were decreased markedly（P all<0.05）,the rate of CD4/CD8 was
higher in patient group than in control group, the percentage of positive
CBV-IgM and CBV-RNA were decreased significantly.
Conclusion: Serum CK-MB and cTnI
were markers with high sensitivity and specificity for cardiac damage and
can aid in the diagnosis of myocarditis or myocardial injury, which being
increased may be viral directly affect cardiac myocyte in early stage, and
due to immunofunction disorder result in cardiac myocyte injury in late.