AN EXPERIMENTAL STUDY ON EFFECT OF BFGF ON CHANGES OF
HISTOLOGY OF SPLIT THICKNESS SKIN
Fu Yuexian, Xiang Daili, Mi Can, etal
Department of plastic Surgery,Children’s Hospital of Chongqing Medical
University, Chongqing, China
Objective: To investigate the
effect of the extrinsic bFGF on changes of histology of experimental split
thickness skin.
Methods: A model of the
autografting of split thickness skin on guinea pig was used. All the guinea
pig were randomly divided into four groups:i.e. A. normal control group. B. 300Au bFGF/ml
group. C. 600 Au bFGF/ml group. D. 900 Au bFGF/ml group. At the times of 1,
2, 4 postoperation week,the
dermal grafts were excised. Then the dermal grafts were observed with the
methods of routine histology and electron-microscope. The amounts of
capillary and the density of fibroblast of the derma were computed.
Results: In 1 postoperation week,the multiplication of the
capillary、fibroblast and collagenous
fiber were appeared in all groups and those were obvious in D group,except for A group. In 2
postoperation week,the
obvious multiplication of the capillary、fibroblast
and collagenous fiber were appeared in B, C, D groups,those were especially obvious in D group. In 4
postoperation week,the
light degree of multiplication of the capillary, fibroblast and
collagenousfiber were appeared,the
defference among each group was not obvious.
Conclusion: Extrinsic bFGF has the
effect of promoting the multiplication of the capillary、fibroblast and collagenous fiber of experimental
split thickness skin,the
effect would be helpful to the healing of the skin and the repair of the
wound.