THE RESISTANCES OF PENICILLIN AND
AMPICILLIN TO COMMON PATHOGENIC BACTERIA ISOLATED FROM NEONATES WITH
INFECTIONS
Yu J-L, Wu S-X
Institute of
Pediatrics, Chongqing Medical
College, Chongqing, China
Objective: To
search the resistances of penicillin and ampicillin to common bacteria
causing neonates infections.
Methods: 2244 strains
were isolated from 1987 to 1998 and their antibiotic susceptibility tests
were performed by using K-B disk diffusion tests.
Results: The
resistant rates of penicillin and ampicillin were 83.1% and 85.2%,
respectively. Ampicillin had significantly higher resistant rates in 1990’s
than in 1980’s (87.5% versus 69.9%,χ2
=33.442 P=0.001).There were higher resistant rates to ampicillin
both in Gram-negative and Gram-positive bacteria, and more seriously in Gram-positive
bacteria whose resistant rates were 95.2%. The general resistant rates were
higher in group of nosocomial infections than group of infections acquired
outside of hospital (to penillin, 92.0%versus 81.6%, χ2 =11.363，P=0.001；to
ampicillin, 96.0% versus 82.7%,χ2=28.287，P=0.001). The
sensitivity rates of 578 strains bacteria to penicillin and ampicillin were
only 16.3% and 18.9%, respectively, and the combined susceptibility tests
were only 21.6%，χ2=2.116，P=0.146 .
Conclusions:
There are quite serious resistances of penicillin and ampicillin to
pathogenic bacteria isolated from neonates with infections.