Jia H-Q, Yu J-L

Children’s Hospital, Chongqing Medical College, Chongqing, China


Objective: To investigate the curative effect to high fever in children by Xingnaojing injection---a kind of preparation of Chinese traditional medicine consisted of muskiness, borneol, gardenia and tulip.

Methods: Clinic trial as follows: From Apr. to June 1998, 77 children with high fever (axilla temperature39) in outpatient department were randomly divided into two groups. The distribution of age between the treatment group and control group was not different statistically. The distribution of diseases was 43 cases of acute upper respiratory infection, 8 cases of purulent tonsillitis, 2 cases of bronchitis, 1 case of pneumonia and 1 case of diarrhea in treatment group, while 17, 4, 1, 0, 0,respectively, in control group. The Xingnaojing injection 0.4~0.6ml/kg.d adding into 10% glucose fluid 100 ml was intravenously infused in treatment group, while the other group didn’t used this injection. Antibiotics were used in both groups. The temperatures were taken after beginning of transfusion 1, 2, 3 and 4 hours. At the same time, the specially observing of rash and convulsion were made. Efficacious outcome was defined if the patient’s high temperature became normal.

Results: The effective rate in the treatment group 58.2%(32/55), with 2 cases(3.6%)in one hour, 15 cases(27.3%)in two hours and 31 cases (56.4%)in three hours defervesced. But only 7 cases of 22(31.8%)defervesced in 4 hours. Significant difference (χ2=4.387P0.05) existed in the two groups. Six of 8 infants suffering from purulent tonsillitis, temperatures fell to normal during 4 hours’ Xingnaojing infusion. But all 4 cases of purulent tonsillitis were not defervesced in 4 hours.The rash and convulsion didn’t appeared in both groups.

Conclusion: Intravenous Xingnaojing infusion is effective and safe for controlling children’s symptom of high fever.