P -
TRANSFER FACTOR ORAL SOLUTION COMBINED WITH KETOTIFEN DECREASED THE
INCIDENCE OF ASTHMA FOLLOWING BRONCHIOLITIS
Huang Y, Zhang R-Y
Children¡¯s Hospital, Chongqing
University of Medical Sciences, Chongqing, China
Objective: To evaluate the efficiency
of P-transfer factor oral solution (P-TFO) combined with ketotifen (KTF) in
decreasing the incidence of asthma following bronchiolitis.
Methods: 50 patients with
bronchiolitis were given P-TFO and KTF compared with 46 patients with
bronchiolitis without the treatment of P-TFO and KIF. The total course was
3~6 months and the average time of the following up was 1 year. Serum level
of IgE, IgG, IgA, IgM and T lymphocyte subsets were tested before and after
the treatment.
Results: 3/50 (6%) of the patients
with bronchiolitis receiving P-TFO and KIF developed asthma compared with
13/46 (28.3%) of the controls with bronchiolitis (P<0.01). The immune
function of the patients with bronchiolitis receiving P-TFO and KIF
improved. The serum level of IgE and the ratio of CD4/CD8 decreased,
and the CD3,CD8 counts were increased after the
treatment.
Conclusions: P-TFO combined with
KIF provided an effective way to decrease the incidence of asthma following
bronchiolitis.