Research on the function of MDR1 gene in
blood-testis barrier of testis malignant tumor
LI
YC , JIN XQ
Children's Hospital, Chongqing University of
Medical Sciences, Chongqing, China
Objective: To research on the
mechanism of blood-testis barrier of testis malignant tumor in order to
choose effective anticancer drugs and reverse the multidrug resistance
(MDR)
Methods: Use P-plycoprotein
(P-gp) monoclonal antibody JSB1 to combine with the immunohistochemical
method to measure the position and intensity of P-gp on different cells of
malignant tissues of testis.
Results: The expression rate and
intensity of P-gp on endothelial cells of capillaries in tumor tissue was
much higher than that on tumor cells (P<0.01).
Conclusions: The mechanism of
blood-testis barrier is that there is a high expression of MDR1 gene on the
endothelial cells of capillaries in tumor tissue instead of tumor cells.