THE DYNAMIC CHANGE
PRINCIPLE OF HYPERLIPIDEMIA IN CHILDREN WITH NEPHROTIC SYNDROME AND THE
EFFECT OF LIPOIDE-REDUCEING WITH DRUGS
Wang Mo, Yong-Bai Li, Li Qiu, et al.
Children¡¯s
Hospital, Chongqing University of Medical Sciences, Chongqing, China
Objective:
To investigate the dynamic change principle of hyperlipidemia in children
with steroid sensitive nephrotic syndrome (SSNS) and the effect of
treatment with Duo Xi Kang capsule (DXK).
Method:
Twenty SSNS children were randomly divided into DXK-treated group and
disease control group, other 20 healthy children as the normal control
group. DXK was administered in DXK-treated group and same regular steroid
therapeutic measures were conducted in two groups of SSNS. Then the main
four kinds of blood-lipoides components were determined, such as total
cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol
(HDL-C), low density lipoprotein-cholesterol (LDL-C) before treatment and
at 2nd to 3rd week, 5th to 6th
week, 8th to 10th week after treatment.
Results:
Before treatment the levels of TC, TG, HDL-C, LDL-C were significantly
higher in SSNS children than those in normal children (p<0.001,
<0.001, <0.05, <0.001, respectively). The level of LDL-C in
DXK-treated group was normal and markedly lower than that in disease
control group after the time of 2nd to 3rd week
(p<0.05, <0.01, <0.01, respectively), and at the same time the
levels of TC,TG gradually decreased. In disease control group, though the
levels of TC, TG, LDL-C could decrease naturally after the time of 5th
to 6th week, they were higher than those in normal children at
the end of the observation.
Conclusion:
The results showed that DXK shortened the lasting time of severe
hyperlipoidemia, especially to LDL-C. Therefore it appears that DXK may
reduce the secondary renal injury. But the levels of TC, TG in SSNS was
still higher than those in normal children even in the 8th to 10th
week.