THE
STATE OF CD30+ CELL AND CYTOKINES OF TH2 IN CHILDREN WITH
STEROID SENSITIVE NEPHROTIC SYNDROME
Li Yongbai，Wang Lijia，Li Qiu, et al.
Children’s
Hospital, Chongqing Medical University, China
Objective: To observe the Th2 state represented by the percentage
of CD30 positive cell and the levels of IL-4, IL-5, IL-6 in PBMC as well as
serum IgE in children with steroid sensitive nephrotic syndrome (SSNS).
Method: Assay CD30 positive cells by FACS and interleukin 4,5,6
as well as serum IgE by ELISA, and analysis the rectilinear relation
between CD30 cells and IL-4, 5, 6 as well IgE.
Results: There are the higher percentage of CD30 cells and the
level of IL-4 as well as serum IgE in children with SSNS than that in
health control group(P<0.001,<0.001,<0.005 separately) but no
significance difference be found in the levels of IL-5, IL-6 in both
groups(p>0.20,>0.50) Our results shows there have the positive
rectilinear relation between the percentage of CD30 cell and IL-4(r=0.94
p,0.001) as well serum IgE, (r=0.744 p,<0.001) neither in IL-5(r=-0.387
p>0.20) nor in IL-6(r=0.08 p>0.50).
Conclusions: The abnormal increase of CD30 cells doesn’t mean
the Th2 cell function excessive as a whole. It may be the specific T cell
colon activation only. Th1/ Th2 imbalance not be in children with SSNS in
this material.
Key words: Nephrotic
syndrome, CD30 cell, Interleukin，IgE,
children