THE
STATES OF FUNCTION OF T CELLS AND ROLES OF CYCLOSPRINE A IN CHILDREN WITH
HENOCH-SCHONLEIN PURPURA
LI Q, Yang X-Q, LI Y-B, Wang L-J
Children’s Hospital, Chongqing University of Medical
Science, Chongqing, China
Objective: To observe the states of function of T cells and
to investigate the roles of Cyclosporin A (CsA) in T cells in the children
with Henoch-Schonlein purpura (HSP) in the acute phase.
Methods: The cells count of CD30
expression in Peripheral blood mononuclear cell (PBMC) were determined by
flow cytometry. IgA, IgG, IgM, IgE，Ig
subsets and cytokines were detected by radial immunodiffusion and ELISA.
Results: The serum IgA and IgE
levels, and IgG subsets, IgE, IL-4 and IL-5 levels in the supernatants of
cultured PBMC of HSP patients were increased significantly in contrast to
the normal controls. IL-2 and IFN-γwere
decreased. The raised of IL-5 and IL-4 in the supernatants of cultured PBMC
of HSP patients were related
to the increased of IgA（γ=0.63）and IgE（γ=0.87）
in serum. The leveals of high TH2 cytokines such as IL-4,IL-5 and IL-6could
be affected by CsA in vitro. The TH1 cytokines further were inhibited.
Conclusions: the dysfunction of T
cell were related to the pathogenesis of HSP patients. The inhibition of
CsA on T cells function of HSP patients were showed. To inhibited TH1
function mainly.