AN
EVALUATION OF TWO DIFFERENT THERAPIES ON HELICOBATER PYLIORI-RELATED
GASTRITIS CHILDREN
Yang Y
Children’s
Hospital, Chongqing University of Medical Sciences, Chongqing, China
Objective: To evaluate the therapeutic effect of two different
programs consist of colloidal bismuth subsitrate (CBS) plus amoxicillin
(AMO), furazolidone (FUR) in comparision with standard triple threapy on
Helicobacter pylori (HP)-related gastritis in children.
Methods: Thirty-two children (3 to 13 years old) with gastroscopically
confirmed HP-related gastritis were divided into 2 groups (A, B) at random.
These children were given two different triple therapies. Group A was given
CBS 8mg/kg.d for two weeks. AMO 50mg/kg.d for two weeks. FUR 5mg/kg.d for
one week. Group B was given a standard triple therapy (CBS+AMO+Met), dosage
of CBS, AMO was the same above, Met 15mg/kg.d for two weeks. Gastroscopy
was performed in these patients prior to medication and over 4 weeks after
therapy, HP infection was detected by rapid urease test and histology over
4 weeks after the therapy. All the patients completed the whole study.
Results: (1) The eradication rates of HP were as follow: Group
A: 94.10% (16/17), Group B:86.6% (13/15). The differences were not
significant. (2) 1 and 2 week after therapy, the pain relief rates in Group
A were 70.6%(12/17), 100% (17/17) respectively. Group B were 73.3% (11/15)
and 86.6% (13/15). (3) The side-effects in the two groups (nausea vomiting
diarrhea and a few rashes) were mild. The occurrence rates in groups A, B
were 6%, 13% respectively.
Conclusion: The same effect was achieved in treatment of
HP-related gastritis between two different triple therapies (CBS+AMO+FUR
and CBS+AMO+Met). Low dose of FUR for a week was highly effective and well
tolerated in treatment of HP-related gastritis in children. The side
effects were minor Therefore, the triple therapy composed of CBS +AMO+FUR
seemed to be of great value with the standard triple therapy and a worthy
of study.