CLINICAL SIGNIFICANCE AND TEST OF COXSACKIEVIRUS B IgM IN CHILDREN WITH VIRAL MYOCARDITIS AND DILATED CARDIOMYOPATHY

Zhong JR, Qian YR

Children’s Hospital, Chongqing University of Medical Sciences, Chongqing, China

Objective: To explore the infective condition of coxsackievirus B and the prognosis in children with viral myocarditis and dilated cardiomyopathy.

Methods: Coxsackievirus B IgM in blood serum of 161patients is tested by ELISA.

Results: 54 of 83 patients with myocarditis, 14 of 28 patients with Cardiomyopathy and 15 of 60 patients with upper respiratory tract infection and 1 of 19 health children had positive CVB-IgM. Significant difference of the positive rate were not observed between myocarditis and cardiomyopathy. There are significant differences in positive rate of CVB-IgM between myocarditis and upper respiratory tract infections (x²=20.8, p<0.025); between cardiomyopathy and upper respiratory tract infections (x²=4.33, p<0.05).

Conclusion: The test of CVB-IgM demonstrates clinical significance as early pathogenic diagnosis of viral myocarditis and cardiomyopathy in children and that the long-term or repeated infection of CVB is probably correlated to the occurrence of dilated cardiomyopathy.

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