Text Box: AMEBOMAS OF LIVER AND SPLEEN Persic M1, Paucic-Kirincic E1, Flajsman-Raspor S1, Subat-Dezulovic M1, Morovic M.2 1 Pediatric Clinic¡¯s "Kantrida"; Clinical Hospital Center Rijeka, Croatia 2 Clinic for Infectious Diseases, Clinical Hospital Centre Rijeka, Croatia Abscesses of the liver and the spleen (ALS) present a notable diagnostic and therapeutic problem. They occur rarely, mostly in immunocompromited children. They are frequently caused by aerobic and anaerobic bacteria, but can also be caused by fungi, amebae and other pathogen microorganisms. We report the case of two children who were hospitalised because of amoebic abscesses of the liver and the spleen, and in - one patient - the kidney. Our patients had fever of unknown origin accompanied with unspecific blunt abdominal pain, and inappetence. Enlarged liver and spleen, jaundice and acute diarrhoea were not present on admission. Ultrasound guided fine needle biopsy and aspiration was done only in one patient and both recived metronidazol and paromomycin therapy. Clinically resolution occured soon after the initiation of therapy, while sonographic features of the abscesses persisted for several months. Reviewing the literature, we found very a few cases of spleen amoebic abscesses. 1844