Text Box: DISORDERS OF SERUM LIPID AND INTRACERABRAL VASCULAR VORTEX-FLOW IN KAWASAKI DISEASE Ji SM, Yin HH, Liu Y, Zhang YL, Yuan Y Division of Cardiology, Beijing Children’s Hospital, Capital University of Medical Sciences, Beijing, China Objective: To determine the alterations of serum lipid and intracerebral blood flow, and investigate their relations for patients with Kawasaki disease (KD). Methods: 48 patients (32 male, 16 female) with acute untreated KD were studied within 10 days of illness as well as in subacute phase. 37 of them were undergone the detection of transcerebral Doppler (TCD) for the spectrum of cerebral blood flow and they were divided into 2 groups, 27 showed vortex (Group I) and 10 did not (Group II). There were 30 normal children as healthy control group. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were directly measured. Results: ①For groupⅠof KD, HDL/TC and HDL/LDL decreased when compared with those in group II (p<0.05, p=0.051) in acute stage. ②HDL/TC, HDL/LDL and HDL significantly decreased (p<0.01, p<0.05, p<0.01 respectively) in the acute stage of KD; TG elevated in both acute and subacute stages (p<0.01). ③compared with subacute stage, TC, TG and HDL in acute stage significantly decreased (all p<0.05). Conclusions: This study shows that in KD there were significant vortex in intracerebral arteries and significant decrease of HDL, HDL/TC, HDL/LDL (the predictor of coronary heart disease risk). It suggested that the serum lipid disorder is one of the factors that affect the intraaterial blood-flow in KD, which is characterized as small and moderate vasculitis. 1859