DETERMINATION OF
PLASMA NONPROTEIN-BOUND IRON IN ASPHYXIATED NEWBORNS AND ITS SIGNIFICANCE
Sun JH1, Zhu JX2, Zhang HM3, Wu
SM4
1. 2. 4Xin-Hua Hospital of Shanghai Second Medical
University, Shanghai, China
3 Shanghai Second Medical University, Shanghai,
China
Objective: To
investigate the effects of nonprotein-bound iron on postasphyxia
reperfusion injury.
Methods: Plasma
nonprotein-bound iron were measured with Bleomycin assay in venous blood
from 20 asphyxiated newborns and 20 healthy newborns during 0 to 6 hours, 6
to 12 hours and 12 to 48 hours after birth.
Results: Nonprotein-bound
iron level was significantly elevated in asphyxiated group compared with
the control during 0 to 6 hours and 6 to 12 hours and was higher during 0
to 6 hours (P﹤0.001).
Conclusions: The
observation indicates that nonprotein-bound iron may have an important role
on postasphyxia reperfusion injury.