文本框: PREPUBERTAL SEX AND RACE DIFFERENCE IN FAT DISTRIBUTION HE Q1, 2, HORLICK M1, 3, THORNTON J1, WANG J1, PIERSON JR RN 1, HESHKA S1, GALLAGHER D1, 2 1Obesity Research Center, St. Luke's-Roosevelt Hospital, New York, USA 2Institute of Human Nutrition, Columbia University, New York, USA 3Babies Hospital, College of Physicians & Surgeons, New York, USA Objective: Central fat distribution is recognized as a human cardiovascular risk factor. Sexual dimorphism of fat distribution is thought to emerge during puberty. Race differences in fat distribution are clearly evident in adults, but are less well characterized in prepubertal children. The aims of this study were to investigate sex and race (African-American, Asian and Caucasian) differences in body fat distribution in prepubertal children. Methods: Regression analysis was used to explore fat distribution in 358 children (176 girls and 182 boys) from a cross-sectional cohort, using anthropometry and dual energy X-ray absorptiometry (DXA). Results: In African-American and Caucasian children, sex differences in fat distribution were evident (P < 0.01) with girls having greater arm, leg and gynoid fat deposits compared to boys, after adjusting for trunk or android fat, age, weight, height, race, and interactions. In Asians, significant sex differences (P < 0.001) presented in gynoid fat deposits only. Caucasian girls had greater total and subcutaneous limb fat than Asian girls (P < 0.01). Caucasian boys had greater total limb fat than Asian boys (P < 0.01). Conclusion: Our results demonstrate both sexual dimorphism and race differences in fat distribution in prepubertal children. Since the association between fat distribution and cardiovascular risk factors have been shown in children, our findings may have implications for understanding population-specific fat distribution related health risks. 1906