文本框: ATHEROGENIC RISK AND OXIDATIVE STRESS IN DIABETIC CHILDREN Bayés R, Campoy C, Blanca E, Baena RMª, Fernández JM, Molina-Font JA Department of Paediatrics. School of Medicine. University of Granada. Spain The dislipidemia demonstrated in type 1 diabetes mellitus (IDDM) influences and contributes to arteriosclerosis phenomena. IDDM patients also show an increase of oxidative stress due to free radical dependent mechanisms, implies in the vascular damage and are probably the ethiopathogenical cause for medium and long time complications. The aim of this study is to analyse the oxidative stress and the atherogenic risk in IDDM children. METHODS: Subjects: Group I (G-I) formed by 47 randomised children with IDDM. They were matched for age and sex with 16 healthy children [group II (G-II)]. Biochemistry: TC, TG, cholesterol joined to high (HDL) (spectrophotometry), very low (VLDL) and low (LDL) density lipoproteins (Friedewald’s formula) in mg/dl; Lipoperoxidation (LPO) in µmol/L (cholorimetry); percentage of glycosilated haemoglobin (HbA1c) (HPLC). Statistical analysis: ANOVA and Student´s “t” test for unpaired data. RESULTS: (G-I vs G-II): TC:175.73±4.58 vs 167.75±6.36; HDLc: 63.03±2.30 vs 59.20±2.53; LDLc:101.40±3.99 vs 96.00±5.04; VLDLc: 11.67±0.88 vs 12.55±1.06; LDLc/HDLc: 1.74±0.12 vs 12.55±1.06; (VLDL+LDL)c/HDLc:1.96±0.14 vs 1.89±0.14; TG:58.37± 4.40 vs 62.75±5.31; total lipids: 234.10±7.43 vs 230.50±10.04; LPO: 36.33±2.22 vs 20.31±1.54, p<0.01; LPO/LDLc:0.40±0.38 vs 0.22±0.25, p<0.05. CONCLUSIONS: It has been reported that in adolescent and in adult IDDM patients, the lipid and lipoprotein levels are normal while the metabolic control of the illness are good. Our results show that the "home-based self-help optimization programme" for IDDM children can diminish the atherogenic risk. LPO is increased in the IDDM children respect to the healthy ones. These results must be taken into account if the paediatric endocrinologist wish to do a good medical and metabolic control, and in order to try a possible treatment with antioxidants to prevent or avoid the IDDM late complications. 1943