文本框: LEPTIN CONCENTRATION IN CORD BLOOD CORRELATES WITH INTRAUTERINE FETAL GROWTH
ZHOU XY, BEN XM
Nanjing Children's Hospital, Nanjing, China

Objective: To determine the concentration of cord serum leptin and its relationship with neonatal anthropometry.
Methods: Sixty-five women and their babies take part in this prospective study. Blood was taken from the umbilical cord at delivery and Serum leptin was measured by radio-immunoassay. Neonatal anthropometric measurements were recorded within 48 hours after delivery. Linear regression analysis was used to explore the relationship between serum leptin concentrations and anthropometric measures.
Results: The leptin concentration (X±SD) in cord blood of the AGA neonates was 10.57±3.03 ng/mL, which were significantly less than that in the LGA neonates (13.15±3.51ng/ml) and more than that in the SGA neonates (8.05±2.69ng/ml). Cord leptin levels correlated with neonatal birthweight, skinfold thickness and Ponderal Index.
Conclusions: there are very strong associations between cord leptin at delivery and birthweight, as well as other anthropometric markers of fetal growth. We hypothesize that leptin might play an important role during pregnancy and fetal development.
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