文本框: HIGH INCIDENCE OF IMPAIRED GLUCOSE TOLERANCE TEST IN OBESE CHILDREN WITH ACANTHOSIS NIGRICAN AND FAMILY HISTORY OF DIABETES Suprasongsin C, Wattanachai A Research center, Ramathibodi hospital, Bangkok, Thailand Type II diabetes has become apparently increasing in children and there in no clear recommendation criteria for screening.Since it is clear that obesity, family history of diabetes and acanthosis nigrican are major risk factors to develop type II diabetes in adults. We therefore performed a preliminary screening in children who have these risk factors. Objecitive: To screen obese children with acanthosis nigrican and family history of diabetes using WHO criteria for typeII diabetes. Patients and Methods : 39 obese children (age=10+/-3 yr; male=22; female=17; wt=55+/-22kgs; ht=142+/-17cms; BMI=26+/-5 kg/sq.m) who has weight by height over 97th percentile with family history of type II diabetes and physical examination revealed positive for acanthosis nigricans were enrolled. Oral glucose tolerance test were performed in all cases. Blood levels for fasting cholesterol were drawn in 29 children. Results: Using WHO criteria, our results show that 12 children (12/39:31%) have impaired glucose tolerance test, 7 children (7/39:18%) have diabetes, 15 children(15/29:49%) have cholesterol levels over 200mg/dl and 22 children (22/29:76%) have at least one risk factors (either abnormal glucose tolerance and high cholesterol). None of these children has polyurea or weight loss. Conclusions: Obese children who have family history of typeII diabetes and acanthosis nigrican should be sceened for cholesterol levels and diabetes. 1972