Text Box: NEONATAL CHOROID PLEXUS CYSTS: INCIDENCE AND ASSOCIATED CHILDHOOD DEVELOPMENTAL OUTCOME Kun-Long Hung, Hung-Tsai Liao Department of Pediatrics, Cathay General Hospital, Taipei, Chinese Taipei Objective: Choroid plexus cysts (CPCs) are incidental findings on sonograms of neonatal head. The true incidence is not known yet. Childhood neurodevelopmental outcome associated with neonatal CPCs has been rarely reported. This study is to determine the incidence of neonatal CPCs and childhood developmental outcome associated with CPCs diagnosed at birth. Methods: During the period July 1997 to June 1998, 2,111 normal newborns underwent brain sonographic examinations as a routine screening. All newborns detected as having CPCs were followed-up with serial sonograms at 1, 2, 4 and 6 months of age. Developmental milestones were evaluated subsequently at follow-up clinics. Developmental assessment was performed with the Denver II Developmental Screening Test. Results: Choroid plexus cysts were identified in 186 neonates (8.8%), with 14(7.5%) bilateral. The mean size of the cysts was 2.6 mm (range 1.1~8.6) with five cysts over 5 mm . All the neonates with CPCs had a normal physical check-up. Follow-up ultrasonic studies were available for 155 children. The cysts regressed spontaneously in majority and, by six month of age, residual cysts were only visible for 18 infants (11.6%). During the clinical follow-up period from 30 to 42 months, developmental outcome revealed normal in all available 179 children. Conclusion: The incidence of CPCs detected at birth was 8.8 %, with most cysts resolving spontaneously. The existence of isolated CPCs in the newborn is neither associated with abnormal physical findings nor with any delay of childhood development. 1978