Text Box: THE ENZYMATIC CHANGES IN CEREBROSPINAL FLUID IN MENINGITIS Seker A, Tokuc G, Vitrinel A, Esmer K Dr.L.Kirdar Kartal Education and Research Hospital, Department of Pediatrics, Istanbul, Turkey Objective: This study was performed to evaluate the biochemical methods that can be done to differentiate the purulant, tuberculous and aseptic meningitis at the earliest manner. Methods: In our study, there were 48 meningitis and 25 control cases. In their cerebrospinal fluid (CSF) SGOT, SGPT, LDH, GGT, ALP levels were determined. Results: When control group was compared with meningitis groups; the levels were not different in the aseptic meningitis but SGOT, LDH, GGT, ALP of CSF were high in bacterial meningitis and SGPT and LDH of CSF were high in tuberculous meningitis. When groups with meningitis were compared with each other; SGOT, LDH, GGT of CSF in cases with bacterial meningitis were high according to aseptic meningitis; CSF LDH and ALP were high in patients with tuberculous meningitis according to aseptic meningitis; and CSF GGT levels were high in cases with bacterial meningitis according to tuberculous meningitis. Also, CSF SGOT, LDH, GGT levels in patients with bacterial meningitis who had complications were high according to patients without complications. Conclusion: As a result, we think that, these enzymes can be used in the differential diagnosis of meningitis but multifactorial determination is needed for their use. 2007