ORAL
SODIUM CROMOGLYCATE IN THE TREATMENT OF FOOD ALLERGY IN CHILDREN
Żur E.1, Kaczmarski M.2
1 Children Teaching
Hospital, Białystok, Poland
23rd Departament of
Children’s Diseases, Medical University, Białystok, Poland
Objective:
The aim
of this study is to assess efficiency and safety of treatment with oral
sodium cromoglycate(DSCG) in children with various clinical manifestation
of food allergy. Therapeutic effects were also estimeted due to: age of
patient, clinical manifestation of allergy, period when it was recognized,
dosage and form of the drug (solution, powder, capsules), duration of
treatment, methods of trial.
Methods: The examination was
carried out in 150 children aged 0.5-15 years. The division of all examined
children into groups was dependent on different study designs. Group I-
double blind placebo controlled trial- 24 children treated with 2% solution
of DSCG (20 mg/kg/day) or placebo during 4 weeks. Group II– open fashion-
46 children treated with capsules DSCG (Nalcrom)-(20-40 mg/kg/day) compared
with controll group; 50 children treated with ketotifen, either during 4-32
weeks. Group III- single-blind cross over study- compared effects of
DSCG-solvent powder (Cropoz G) to the other drug from the same chemical
family, during either 6 weeks (dosage 20-40 mg/kg/day). Elimination diet
was applied in all children. Estimation of therapeutic effects based on:
physical examination and compare Score value before and after treatment in
each group, and results of questionary filled in by parents.
Results: A statistically significant
reduction of Score value were observed after oral cromolyn therapy in
groups II and III, in group I - effects were not better than placebo.The best therapeutic
effects were observed in patients with gastrointestinal and multiorgans
allergy, with longterm administration and higher dosage of drug. Side
effects were found in 8.7%.
Conclusion: Oral sodium cromolycate
is effective and well tolerated in the treatment of food allergy in
children.