ORAL SODIUM CROMOGLYCATE IN THE TREATMENT OF FOOD ALLERGY IN CHILDREN

Żur E.1, Kaczmarski M.2

1 Children Teaching Hospital, Białystok, Poland

23rd Departament of Children’s Diseases, Medical University, Białystok, Poland 

 

Objective: The aim of this study is to assess efficiency and safety of treatment with oral sodium cromoglycate(DSCG) in children with various clinical manifestation of food allergy. Therapeutic effects were also estimeted due to: age of patient, clinical manifestation of allergy, period when it was recognized, dosage and form of the drug (solution, powder, capsules), duration of treatment, methods of trial.

Methods: The examination was carried out in 150 children aged 0.5-15 years. The division of all examined children into groups was dependent on different study designs. Group I- double blind placebo controlled trial- 24 children treated with 2% solution of DSCG (20 mg/kg/day) or placebo during 4 weeks. Group II– open fashion- 46 children treated with capsules DSCG (Nalcrom)-(20-40 mg/kg/day) compared with controll group; 50 children treated with ketotifen, either during 4-32 weeks. Group III- single-blind cross over study- compared effects of DSCG-solvent powder (Cropoz G) to the other drug from the same chemical family, during either 6 weeks (dosage 20-40 mg/kg/day). Elimination diet was applied in all children. Estimation of therapeutic effects based on: physical examination and compare Score value before and after treatment in each group, and results of questionary filled in by parents.

Results:  A statistically significant reduction of Score value were observed after oral cromolyn therapy in groups II and III, in group I - effects  were not better than placebo.The best therapeutic effects were observed in patients with gastrointestinal and multiorgans allergy, with longterm administration and higher dosage of drug. Side effects were found in 8.7%.    

Conclusion: Oral sodium cromolycate is effective and well tolerated in the treatment of food allergy in children.

 
2028