SERUM CONCENTRATION OF
GROWTH HORMONNE, INSULIN LIKE GROWTH FACTOR-1, PROCOLLAGEN-1 AND PROLACTIN
IN INFANTS AND CJILDREN WITH GROWTH DISORDERS
Mohamed NG*, El-Rehany M**, Nageeb HF***, Sallam SA*
and Abdel-El-Maboud M*
* Pediatric Department,
El-Minia University, El Minia, Egypt
** Biochemistry
Deparetment, El-Minia University, El-Minia, Egypt
*** Pediatric
Department, Cairo University, Beni-Suef Branch, Egypt
Objectives: The aim of this study
was to determine the relationship between growth hormone (GH) and insulin
like growth factor-1 (IGF-I) and to show their value together with
procolagen (PINP) and prolactin (PRL) in diagnosis of growth disorders.
Methods: GH, IGF-I, PINP and PRL
were measured by immunoradiometric assay (IRMA) in serum samples of two
groups. Group 1 included seventy patients with growth disorders (sixteen
patients with primary growth disorders, twenty-four patients with secondary
growth disorders and thirty patients with idiopathic short stature and
group 2 included twenty-five healthy controls.
Results: Serum levels of GH,
IGF-I, PINP and PRL were significantly lower in the group with growth
disorders than in the healthy controls. The lowest levels of those markers
were found in patients with secondary growth disorders which are growth
failure resulting from chronic illness or endocrinal disorder. There was a
statistically significant difference in serum levels of GH, IGF-I, PINP and
PRL among different groups of patients.
Conclusion: Serum GH and IGF-I are
essential for maintaining physical growth in healthy infants and children
and in children with growth disorders but other growth factors as PINP and
PRL might be needed for assessment of growth.