THE CLINICAL SIGNIFICANCE OF INOCULATING BCG

Liu Yali, Yang Xiqiang

Department of Immunology,

Chongqing Children’s Hospital, Chongqing, China

 

Objective: The aim of study was to investigate the record of protein purified derivative (PPD) response before and after inoculating BCG in patients with respiratory syncytial virus pneumonia, and the relation between BCG and clinic.

Method: The study objects were divided into two groups. One was treated with BCG, the other was treated with BCG accompanied by immunological regulator IFN-γ,VitaminA.PPD was injected by indermic,and callocity diameter of PPD response was determined in pretreatment or posreatment respectively.

Result: Before intervention, all patients were injected PPD, and all were negative. After 3 months, among the patients with BCG, 50%of PPD response were positive, callocity diameter were between 9-15mm; 25% were below 10 mm; 25% were negative, even in the deltoid section of upper arms with injecting BCG, there were no scar left after purulency. On this condition, BCG was repeatedly injected untill PPD(+).Retrorespect research found that these patients had family history of atopy. In patients with BCG and immunological regulor IFN-γ, VitaminA,PPD response were all positive, callocity diameter wer between 15-20 mm, PPD response of some patients change into positive from negative only spending 2 months.

Conclusion: Compared the result of the PPD response of two groups, BCG, IFN-γ, VitaminA make PPD response become positive in short time, and strong. The rate of recurring weezy and infection was decreased stringly to two groups. Make sure that BCG can alter immunological state, buildup TH1 function, promote cellular immunology, correct TH subsets unbalance, so inoculating BCG may act as a measurement of curing disease with TH subset confusion, especially combinating with immunological regulor IFN-γ,VitaminA, the effect is better.

 
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