THE CONDITION OF THE LIVER IN SEPSIS WHICH
PREMATURELY BORN CHILDREN HAVE
Rakhimova
KV, Nadirova KE
Kazakh State
Medical University
State
Clinical Hospital for Children, Almaty, Kazakhstan
The result and prognosis of sepsis
depends on organs’ and systems’ involving into the process. The condition
of the liver is sepsis was carefully studied among 91 prematurely born
children: 41 children had congenital sepsis, 39 children had umbilical
sepsis, 9 children had intestinal and 2 children - pulmonary sepsis.
Septicemia was observed among 26 children and 65 had septicopyemia.
Different research was carried out such as: morphohistological, functional
and laboratry reseach. The changes of enzymic activity,
ornithinecarbamiltransurethrasa (oct), urokinasa (UR), histidase (HI),
arginasa (arg), a-QBDQ, callicris, a1 -ATA, and so on
had the common tendension: by ingreasing the period of hestation, the
seraus activity of enzymes was incread too. During the neonatic period “the
maturing” of separate enzymes in the system of hepaton, the erythron in
ontogenesis happen not egualy; heightened sensibility of OCT and a-QBDQ was
pointed bu infectious - inflammatory diseases. During the sharp period of
diseas the activity of OCT had increased 30 times the size, so the activity
of OCT is a slite indicator of lever’s affection. Among dead children the
activity of OCT, UR, a-QBDQ, SP had been increasing zero level.
Morphohistilogical research of dead children’s liver showed that 2/3 among
them had septic hepaton, 1/3 had morphological picture ofa “shoked” liver.
The metabolic reabilitation failed to keep up with
clinical among 19% of discharged children who had reactiv hepaton; in 6
month’s time serous activity of enzymes became normal. The syndrome of
cytolysis is not typical for peaple suffering from sepsis, during
cholestosis syndrome the huperphosphatesemia was the leading, unfortunately
the genesis of huperphosphatesemia is still unknown. The hitting of
cytosoline, mitochondrial and microsomic enzymes into the blood happened
due to the heightened permeability of cellular membranes, organella
hepatocits and necrocis of hepatocits. So the activity of enzymes might be
used as markers of the liver’s affection.