HLA SYSTEM FOR PNEUMONIA
OF PREMATURE
Abykanova GU, Rahimova KV
Kazakh State Medical University Named Under Asphendiyarov S.D.
Almaty, Kazakhstan
The fact is that HLA
system plays the leading hand in decision making of such problems as
genetic determinancy of pathology. The determination of association of
diseases (pneumonia, sepsis) with the HLA system antigens is becoming
actual.
The object of this
investigation is to research HLA antigens association according to the
locuses for pneumonia of premature.
There were observed 16
premature with the pneumonia (9 girls and 7 boys, two thirds of them kazakh
people) that had serious background. The five women had born children with
Caesarian section. Seven women had long toxicosis, two of them felt
eclampsy with the chronic DVS syndrome. Half of the women had anemia and
other pregnancy and childbirth pathology. I-II degree of premature had 8
children and II -III degree of premature had 8 children respectively. 6
children felt sick with the pneumonia as the result of trauma during giving
birth. The rest of them had encephalopatia and there was §Ù§Ñ§Õ§ß§Ö§Þ§à§Ù§Ô§à§Ó§Ñ§ñ herniathc. The pneumonia was taking it1 medium heavy
course with 9 children and the other children had heavy course.
HLA system was observed
in standard microlymphotoxical test. The investigation of three couples of
twins shows the same HLA system antigens of each child of the twins.
The analysis of generic
disposition established the following genotypes:
A2, 3; B18 / A26.30;
B13, 49 / A2, 9; B35, 40 / A2, 24; B51, 62 / A9, 10; B5 / A2: B46, 73/. The
frequency in control group exceeded in the locus HLA A - A2.