INHALED NITRIC OXIDE THERAPY BY CPAP WITH NASAL PRONGS FOR THE
NEWBORN WITH HYPOXIC RESPIRATORY FAILURE AND FOLLOW-UP TO 30 MONTHS OF
AGE
Mai ZG, Liang SX, Tan JJ, Gu HL
The First People's Hospital of Foshan City, Guangdong, China
Objective: To investigate the effect of inhaling
nitric oxide (NO) on healing period and neurodevelopment of the newborn
with hypoxic respiratory failure.
Methods: 42 cases of neonate were randomly assigned to
inhale 10~20 ppm NO by continuous positive airway pressure (CPAP) with
nasal prongs (n=21) or have control therapy without NO (n=21). The two
groups did not differ for baseline characteristics (gestational age, birth
weight and age). The PaO2 and transcutaneously measured arterial
oxyhemoglobin saturation (TcSO2) of the newborn were examined regularly or
continuously. Body weight, length measurement and neurodevelopmental
assessment of the cases occurred at 6 to 30 months of age.
Results: The times of TcSO2 and PaO2 reached 93% and
9.33 kPa (70 mmHg) in therapy group (34.5±48.4 hours and 39.8±44.5 hours
respectively) was shorter significantly than that of control group
(87.8±54.3 hours and 102.9±22.0 hours respectively, p<0.05).The times of
therapy group with CPAP, inhaled oxygen by headhood and stayed in hospital
(74.2±23.1 hours, 91.8±72.3 hours and 19.1±13.5 days respectively) were
also shorter than that of control group(125.1±10.5 hours,140.7±72.9 hours
and 25.9±6.9 days respectively, p<0.05).The cases of therapy
group / control group followed-up at 6,12,18,24,30 months of age were 13/14、11/12、9/8、8/6、6/5 respectively. There
was not significant difference between the two groups in the body weight,
length, mental development index (MDI) and psychomotor development index
(PDI).
Conclusion: Inhaled NO by CPAP with nasal prongs
shortten the time for the neonate to correct the hypoxic respiratory
failure, inhale oxygen and stay in hospital. There were not poor effect
recently on physique and neurodevelopment of the newborn inhaled NO.