INHALED NITRIC OXIDE THERAPY BY CPAP WITH NASAL PRONGS FOR THE NEWBORN WITH HYPOXIC RESPIRATORY FAILURE AND FOLLOW-UP TO 30 MONTHS OF AGE 

Mai ZG, Liang SX, Tan JJ, Gu HL

The First People's Hospital of Foshan City, Guangdong, China

 

Objective: To investigate the effect of inhaling nitric oxide (NO) on healing period and neurodevelopment of the newborn with hypoxic respiratory failure.

Methods: 42 cases of neonate were randomly assigned to inhale 10~20 ppm NO by continuous positive airway pressure (CPAP) with nasal prongs (n=21) or have control therapy without NO (n=21). The two groups did not differ for baseline characteristics (gestational age, birth weight and age). The PaO2 and transcutaneously measured arterial oxyhemoglobin saturation (TcSO2) of the newborn were examined regularly or continuously. Body weight, length measurement and neurodevelopmental assessment of the cases occurred at 6 to 30 months of age. 

Results: The times of TcSO2 and PaO2 reached 93% and 9.33 kPa (70 mmHg) in therapy group (34.5±48.4 hours and 39.8±44.5 hours respectively) was shorter significantly than that of control group (87.8±54.3 hours and 102.9±22.0 hours respectively, p0.05).The times of therapy group with CPAP, inhaled oxygen by headhood and stayed in hospital (74.2±23.1 hours, 91.8±72.3 hours and 19.1±13.5 days respectively) were also shorter than that of control group(125.1±10.5 hours,140.7±72.9 hours and 25.9±6.9 days respectively, p0.05.The cases of therapy group / control group followed-up at 6,12,18,24,30 months of age were 13/1411/129/88/66/5 respectively. There was not significant difference between the two groups in the body weight, length, mental development index (MDI) and psychomotor development index (PDI).

Conclusion: Inhaled NO by CPAP with nasal prongs shortten the time for the neonate to correct the hypoxic respiratory failure, inhale oxygen and stay in hospital. There were not poor effect recently on physique and neurodevelopment of the newborn inhaled NO.

 

 
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