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SIGNIFICANCE OF LYMPHOCYTE'S CHANGE IN PERIPHERAL BLOOD IN CHILDREN'S ACUTE LYMPHOCYTE LEUKAEMIA DURING CHEMOTHERAP Qu Fan，Wu Xiuhua, Dong Wei, etc The Forth Hospital of
HeBei Medical University Pediatrics Shijiazhuang, HeBei, China Objective: By observing the change
of lymphocyte in peripheral blood in children' s Acute Lymphocyte Leukemia
(ALL) during the chemotherapy, we are to know the chemotherapeutic effect and
estimate the prognosis of ALL. Material and Methods: A number of cases were
selected randomly from the hospitalized patients in our department since
1995. According to the first chemotherapeutic effect, which was the results
of puncture to bone marrow at the end of the first hemotherapy, we divided
the cases into common group and refractory group. There are four cases in
common group, aged from 2-10, three boys and one girl. In refractory group,
the number of the cases is the same, aged from 2-12, two boys and two girls.
We examined the peripheral blood twice every week during the chemotherapy. We
had taken 0.5ml blood from peripheral vein each time, and added 0.1 ml EDTA
to it, and analyzed the blood with counter JT (which is made in America).
Then, the retrospective analysis of the proportion change of lymphocyte in
peripheral blood during the chemotherapy was given. Results:
With the chemotherapy prolonged, the proportion of lymphocyte in common group
was decreased remarkably but that of the refractory group was increased.
There was a significant differentiation on the twenty-fourth day of chemotherapy.
The following chart shows the data of the two groups. The change of the
proportion of lymphocyte in peripheral blood during the chemotherapy between the two groups
(The average)
Groups
The days of the chemotherapy
Refractory group
59.33 62.45 68.95 72.63 * 70.925*
Common group
74.10 57.93 50.60 32.28 34.70
* p<0.05 Conclusions: The proportion changing
of lymphocyte in peripheral blood during the chemotherapy in children' s ALL
is related to the therapeutic effect and we can guide the treatment and
estimate the prognosis through keeping watch on the proportional change of
lymphocyte in peripheral blood. |
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