VISCERAL LEISHMANIASIS -TEN YEARS ANALYSIS OF EFFICACY
OF TREATMENT
Trajkova-Antevska
Z, Zisovski N, Muratovska O,
Glamocanin S, Martinova K
University
Children’s Clinic, Skopje, Macedonia
Objective: Mediterranean visceral Leishmaniasis-Kala azar is
endemic disease in some areas in Macedonia. The aim of the study is to
evaluate the efficacy of the treatment of this disease with
Nmethyl-glucamine antimonate (Glucantime).
Methods: During past ten years were diagnosed and treated 29
infants and children, 12 male, on age from 5 months to 12 years. Five of
them were infants. All patients underwent standard clinical examination,
biochemical investigation and bonemarrow aspiration. In one patient was
done biopsy of a lymphonode and in one a hepatic biopsy. All patients were
treated with Glucantime (60mg./kg. BW) i.m., in 14 days cycles and pause of
14 days between. The cycles were repeated accordingly to the clinical and
the biochemical data before each cycle. The treatment was stopped when
biochemical analyses and bonemarrow aspirates were normal.
Results: One patient was cured after the first cycle, 7 patients
after two cycles, 20 patients after three cycles and one after five cycles (in circumstances of lacking of
another effective drug). There were not any toxic side effects of the drug.
Conclusion: Treatment with Glucantime in 14 days
cycles and pause of two weeks is efficient and without toxic effects, even
when the cycles are repeated several times, easy for application and not
very expensive.