Primary malignant bone
tumors and congenital diseases in children
Glamocanin S1, Pisevska C1, Muratovska O1,
Krajcer Z3, Martinova K1, Antevska Z 1
1 University
Children's Hospital, Skopje, Macedonia
3 St.
Luke's Episcopal Hospital & Texas Heart Institute, Houston, USA
Objective: The aim of this
study is to present the incidence of congenital diseases between patients
with Primary malignant bone tumors (PMBT) in childhood and adolescence in
Macedonia.
Methods and Results: PMBT in
childhood and adolescence in Macedonia count over 3.3% of all malignant
diseases. Between Jan. 1979 and Jan. 2000, 46 patients with PMBT were
treated at the University Children's Hospital in Skopje (23 with
osteosarcoma, 22 with Ewing Sarcoma-ES and one with Chondrosarcoma). Among
all children with PMBT only one patient had congenital disease. This is a
young girl with localized ES of the right humerus, who also suffered from
congenital heart disease consisting of patent ductus arteriosus (PDA). PDA
was diagnosed at the age of 6 months. At the age of 11, X¨Cray of the right
hand, bone scintigraphy, surgical biopsy and histopathology revealed an ES
of the right humerus. She was treated with chemotherapy according to the
VACA protocol, followed by radiotherapy for local treatment. The girl was
in complete remission of ES from 1988 until now. Her heart disease
progressed through congestive heart failure. She was operated at Texas
Heart Institute in 1993. In 1997, she was pregnant and she gave birth to a
healthy boy without any congenital anomaly.
Conclusion: The unusual incidence of congenital
diseases between patients with PMBT is not approved by this study. The
combined therapy of ES is effective and could result in long-term survival.