THE CONCENTRATION OF BETA-2-MICROGLOBULIN IN SERUM OF NEWBORNS WITH HYPERBILIRUBINAEMIA

Szponar E¹, Furmaga-Jablonska W¹, Chrzastek-Spruch H¹, Polkowska G¹, Zatorska-Karpus M¹, Jagiello-Wojtowicz E²

¹ Department of Paediatrics, Medical University School of Lublin, Poland

² Department of Toxicology in Lublin, Poland

Objective: The aim of the study was to explain the relationship between indirect hyperbilirubinaemia and the beta-2-microglobulin content (b₂m) in the serum of healthy, full-term new-borns with physiological jaundice and in new-borns with jaundice of breast milk.

Methods: The study included 90 new-borns that were divided into a sub-group with breast milk jaundice (bilirubin level>12,9mg/l) - 47 new-borns and a control group with physiological jaundice - 43 new-borns. The b₂m assays were performed with fluoroimmunological method using ready DELFIA sets. Statistics was done with t-Student test (p < 0,05 was significant).

Results: b₂m concentration in serum of new-borns with breast milk jaundice on the third was day 3,24±0,09mg/l, on the sixth day was 2,77±0,10mg/l and on the ninth day it was 2,83±0,10mg/l. In the control group on the third day b₂m level was 3,36±0,13mg/l, on the sixth day 2,91±0,09mg/l. No statistically significant differences were confirmed in the b₂m level in new-borns with breast milk jaundice as compared with control group. The level of b₂m in the serum of the new-borns on the third day was significantly higher than on the sixth day both in the studied group (p<0,001) and in the control group (p<0,01).

Conclusions: The increase of indirect bilirubin level in the healthy and full term new-borns does not influence the level of b₂m in the blood.

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