SERUM MARKERS OF BONE TURN-OVER IN NEWBORNS

Furmaga-Jablonska W 1, Kulik-Rechberger B 1, Kozlowska M 1, Kosciesza A 1, Spruch-Stepnik A2

1Department of Paediatrics, Medical University School of Lublin, Poland

2University Children¡¯s Hospital, Lublin, Poland

 

Objective: The aim of our study was to establish the level of C-terminal propeptide Type-I collagen (PICP) as a marker of bone formation and C-terminal telopeptides of Type-I collagen (CrossLaps) as a marker of bone resorption in serum of appropriate-for-gestational age (AGA) newborns.

Methods: The research included 47 AGA newborns ¨C 32 boys and 14 girls, born in 26-41 week of pregnancy; 28 of them were full-term and 19 were preterm. The level of PICP (Metra Biosystem, USA) and CrossLaps  (Osteometer, Denmark) were assayed with ELISA method. Statistic was performed with t-Student and Pearson correlation tests. P < 0,05 was regarded as significant.

Results: In newborns serum mean level of PICP was: 2073,8 ¡À 555,1 ng/ml and mean level of CrossLaps was: 17413,8 ¡À 5932,5 pM/l. There were no statistical differences in the level of PICP and CrossLaps in boys and girls, as well as in full-terms and preterms (p>0,05). Serum level of CrossLapss correlated significantly with birth weight  (r=0,39,p<0,05) and length (r=0,36,p<0,05) as well as with gestational (r=0,37,p<0,05) and chronological age (r=0,36,p<0,05) of newborns. The negative correlation was shown for PICP level and gestational age of investigated children (r= -35,p<0,05). There was no statistical correlation between the PICP and CrossLapss level in new-borns serum.

Conclusion: Despite the very high level of bone turn-over there is no proportional correlation between the processes of bone formation and resorption in newborns.

 
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