MARKERS OF COLLAGEN TYPE I TURNOVER IN RELATION TO
GROWTH VELOCITY IN GIRLS DURING PUBERTY
Kulik-Rechberger B1, Kozlowska M1, Rechberger T2
1 Department of Paediatrics, Medical University
School of Lublin,
2
Dept. of Gynaecological
Surgery, Medical University School of Lublin,
Poland
Objective: The purpose of our study was to estimate the
serum concentration of carboxyterminal propeptide of type I procollagen (PICP) and carboxyterminal
cross-linked
telopeptide of type I collagen (ICTP) in healthy pubertal
girls and relation of these markers of bone and skin collagen turnover to
growth velocity.
Methods: One
hundred and seventy five girls aged
from 9,8 to 14,7 years, in various stages of pubertal development were
examined and annual increases of body height, body weight, leg length,
bi-iliac breadth were analyzed concomitantly with PICP and ICTP
concentrations, estimated by the RIA method. Girls were divided into three
groups according to Tanner stages of breast development; 68 girls were in
the first group (stage 1), 89 in the second group (stage 2 and 3,
undergoing growth spurt) and 18 in the third group (stage 4 and 5).
Results:
The highest PICP concentration was found in the second group (249.8±100.74mg/l)
and this value was higher than that in the first (201.87±88.67mg/l)
and third (167.65±55.91mg/l)
groups (p<0,001). Also the highest concentration of ICTP was observed in
the second group (10.01±5.33mg/l) and this value was
higher (p<0,004) than in the first group (8.04±2.73mg/l) and almost higher
(p<0,06) than in the third group (7.67±3.52mg/l). Significant
positive correlation was found between PICP and annual increase in body
height (r=0,36; p<0,001).
Conclusion: Collagen biosynthesis
marker correlates positively with velocity of growth height during pubertal
development.