DISORDERS OF LIPIDS METABOLISM IN CHILDREN AND YOUTH WITH ARTERIAL
HYPERTENSION
Chrzastek-Spruch
H., Pac-Kozuchowska E., Szajner-Milart I.
Department
of Paediatrics, Medical University School of Lublin, Poland
Objective: Atherosclerosis regarded as a metabolic,
civilisational disease is a serious social problem. Early prevention of
atherosclerosis requires an early detection of the risk factors. One of
these is hypertension.
Methods: The study included 45 children with arterial hypertension aged
7-18. There were 28 children (16 girls and 12 boys) with idiopathic
hypertension and 17 children (10 girls and 7 boys) with hypertension of
renal origin. In all of the studied children in the blood serum sampled
before breakfast the following parameters were assayed: concentration of
triglicerides, total and HDL cholesterol was determined by means of Cormey
set in Cobas-Mira S apparatus. The level of LDL and VLDL cholesterol was
determined with an indirect method.
Results: The obtained results were compared with earlier developed own
standards. In the children with idiopathic hypertension there were
confirmed higher level of triglicerides and of total cholesterol, LDL and
VLDL cholesterol, both in boys and girls as compared with the control
group. In children with renal hypertension the mean values of
triglicerides, total cholesterol and
LDL and VLDL cholesterol were also higher and the values of HDL
cholesterol were lower as compared with the control group.
Conclusion: The increased concentration of triglicerides
and of atherogenic fraction of LDL and VLDL cholesterol diagnosed in
approx. 60% of children and youth with arterial hypertension confirm the
presence of atherosclerotic risk factors in this group of patients.