THE USE OF INSTENON IN THE TREATMENT OF TOXIC ENCEPHALOPATHY IN YOUNG
CHILDREN
Akhmedova D.I., Masharipov Yu.
The First State Medical Institute, The
Republican Research Centre of Emergency Medical Care, Tashkent, Uzbekistan
The
severe course and unfavourable outcome of the acute respiratory diseases
are often associated with development of the toxic encephalopathy
(neurotixcosis) due to dominating hypoxic brain damages and, as our
investigations showed, low immunologic reactivity in young children. In
this connection the search of new highly effective pathogenically based
method of correction of these states is actual and necessary. For this
purpose we used the drug instenon in the complex treatment of 51 young
children with toxic encephalopathy. Our choice was explained by favourable
combination of vasoactive and neurotrophic grugs being capable to effect
under the condition of hypoxia. Instenon was used in dose 15-20 mg a day
additionally to etophilline. The agent was administered intravenously or via
dropper with 5%glucose sollution two times. The investigations performed
showed that in children receiving instenon the vital functions (breathing,
circulation, nervous system) had been stabilized and restored faster. The
efficacy of the grug instenon was confirmed by data of encephalography,
echo-encephalography, as well as by immunologic investigations. Thus, there
was noted reliable improvement of immunologic indicators; CD3 - 55,0+_3,8;
CD4 - 36,0+_2,6; CD8 - 17,0+_1,6; CD16 - 14,0+_0,8; CD22 - 10,7+_0,8;
ASLbrain 2,3+_0,6; ASL cor -3,2+_0,4; ASLpulm - 4,2+_0,4. Before treatment
these parameters were 47,0+_3,6; 43,4+_2,5; 15,6+_3,5; 17,0+_2,8;
0,19+_0.9; ASLbrain 4,5+_0,4; ASLcor 5,3+_0,6 and ASL pulm 5,0+_0,5,
respectively. On the basis of results obtained it may be concluded about
favourable perspective for use of instenon in the treatment of toxic
encephalopathy.