CHANGES OF BRAINSTEM AUDITORY AND SOMATOSENSORY EVOKED
POTENTIALS IN LATE INFANTILE FORM OF METACHROMATIC LEUKODYSTROPHY
Yang J, Chen Q, Yang
WM
Department of
neurology, Capital Institute of Pediatrics, Beijing, China
Objective: To investigate
the characteristics and clinical value of evoked potentials in late
infantile form of metachromatic leukodystrophy.
Methods: Brainstem
auditory and somatosensory evoked potentials were recorded in 6 patients,
and compared with the results of CT scan.
Results: All of
the 6 patients had abnormal results of BAEP and MNSEP. The main abnormal parameters in
BAEP were latency prolongation in wave I, inter-peak latency prolongation
in I-III and I-V. The abnormal
features of MNSEP were low amplitude and absence of wave N9, inter-peak
latency prolongation in N9-N13 and N13-N20, but no significant change of
N20 amplitude. The results
also revealed that abnormal changes in BAEP and MNSEP were earlier than
that in CT.
Conclusion: The
detection of BAEP and MNSEP in late infantile form of metachromatic
leukodystrophy might early reveal the abnormality of conductive function in
nervous system and might be a useful method in diagnosis.