THE ROLE OF MACROPHAGE INFLAMMATORY PROTEIN –1α IN HENOCH-SCHONLEIN PURPURA NEPHRITIS
Huang
D-L，Yi Z-W，He Q-N，Wu
X-C，He X-J
Laboratory of Pediatric Nephrology, The Second Hospital of Xiangya
school of medicine, Central South University, Changsha, China
Objective: To evaluate the role of
MIP-1α in the pathologic change, clinic manifestation and clinic course in HSPN,
and to demonstrate the hypothesis that MIP-1α via the chemokine receptors
participate in the pathophysiology of HSPN by recruiting and activating
macrophage.
Methods: 22 cases with HSPN and 12
control case were enrolled. We investigated the presence of MIP-1α protein
and the infiltration of CD68-positive macrophage in the kidneys.
Result: In HSPN group
MIP-1α-positive cells can mainly be found in tubular epithelial、infiltrated inflammatory
cells in mesangium and interstitial areas. In HSPN group, the
intraglomerular and interstitial CD68-positive or MIP-1α-positive cells in
group with crescent were more than those in group without crescent（P＜0.05), and those in group with both proteinuria
and hematuria were more than those in group with either proteinuria or
hematuria（P＜0.05) The intraglomerular and interstitial
MIP-1α-positive cells in group
with course less than 3 months
were more than those in group with course more than 3 months(P＜0.05).the intraglomerular
and the interstitial CD68-positive cells was correlated well with the
MIP-1α-positive cells, respectively. (r=0.664 P＜0.01; r=0.829 P＜0.05＝
Conclusion:
MIP-1α plays an important role in the acute phase of HSPN by recruiting and
activating macrophage. MIP-1α and infiltrating macrophage in renal tissue
were correlated well with the clinicopathological findings in HSPN . The
accumulation and activation of macrophage by MIP-1α may be one of the major
causes of cellular crescents formation in the early phase in HSPN.