Text Box: CHANGE AND MEANING ON DETERMINATION OF T LYMPHOCYTE SUBSET IN CHILDREN WITH KAWASAKI DISEASE Wang Hua1, Cheng PX1, Wang HW1, Wan LJ1, Tao DD2 1Dept. of Pediatrics, 2Molecular Medicine Center of Tongji Hospital, Huazhong University of Science and Technology (HUST), Wuhan, China Objective: To investigate the determination of T lymphocyte subset in children with Kawasaki Disease (KD) and to evaluate their clinical significance. Methods: The peripherals blood CD30+, CD25+, and CD4+ were determined in 11 cases of KD, as well as 11 healthy children with immunocytochemistry and flow cytometry (FCM). Results: The cells positive expression for CD30+ and CD25+ in KD group were evidently much higher than the cells positive expression of control group (P<0.01). The cells positive expression for CD4+ were increase significantly in experimental group compared with control group (P<0.05). Conclusion: T lymphocyte in children with KD are the activated by variety of etiologic agents. It induces the immune responsive reaction. 2365