Text Box: FIVE YEAR EXPERIENCE WITH SEPTICAEMIA IN 2 ANOTHER NEONATAL INTENSIVE CARE UNITS M Sugiyama1, K Maruyama2, Y Nako1, T Koizumi2, A Morikawa1 1 Department of Pediatrics, Gunma University, Gunma, Japan 2 Gunma Children’ s Medical Center, Gunma, Japan Objective: To describe clinical agents and outcomes associated with septicaemia in patients admitted to 2 another neonatal intensive care units; at The Hospital of Gunma University School of Medicine (all patients are in-born infants from maternary cared mothers), and at Gunma Children’s Medical Center (all out-bornes from the local hospitals) Methods: Chart reviews of patients who are hospitalized at NICUs above 2 hospitals from January 1995 to December 1999, and had positive blood culture in their hospitalized period. Results: In Gunma University Hospital, 6 patients were detected among 1049 admissions, all patients were survived, and coagulase-negative staphyrococci (CoNS) (n=3) was the most common pathogen. In Gunma Children’s Medical Center, 63 were detected among 981 admissions. CoNS (n=27), methicillin resistant staphyrococcus aureus (MRSA) (n=22), group B streptococcus (GBS) (n=7) were dominating pathogenes. The overall mortality in septicaemia was 14%. The annual incidence of septicaemia increased significantly, from 1.6- 1.7% during the first 2 years to 8.2- 8.8% during later 3 years. 48% of all septicaemia infants were extremely low birth weight , and 80% had onsets after 72 hrs after deliverying. Conclusions: We should make more efforts for reducing nosocomial bacterial infections in NICUs, with further inestigations considering about social or medical conditions in which each NICU is located. 2431