Text Box: FREQUENCY OF RISK FACTORS ASSOCIATED WITH HYPERCHOLESTEROLEMIC ADOLESCENTS Juarez MIE, Martin J, Mejia AJM, Sciandra RM, Gonzalez SH, Games EJ, Vilchis QO, Nunez TF, Mirando GD, Mercado AJ. Pediatrics' Hospital, Mexican Institute of Social Security, Mexico Objectives: To determine the frequency of risk factors associated with hypercholesterolemia in adolescent. Methods: Cross-sectional analytical study. 412 adolescents from 12 to 16 years old were studied. A sample of 3ml of blood was obtained from them after 12 hours of fasting and 15 minutes of resting to know cholesterol levels. A questioner was applied to all the parents about the risk factors of their children. Relative Risk (RR) was obtained with al interval of confidence of 95%, it was used the program Epi Info 6. Results: 23% (96) of the adolescents had levels of cholesterol in borderline and 12.4% (51) had hypercholesterolemia. The association between adolescents with hypercholesterolemia and risk factors was: RR 3.72 (p<0.005) in those adolescents with family history of myocardial infarction in their parents, RR 4.03 p<0.005) with the family history was on their uncle or aunts, RR 2.63 (p<0.005) with family history of hypercholesterolemia, RR 1.15 with family history of Obesity (NS) and RR 2.42 (P<0.05) with family history of Diabetes Mellitus in their parents. Conclusions: It was confirmed that risk factors such as family history of myocardial infarction, familiar hypercholesterolemia, and diabetes mellitus represent a risk to become hypercholesterolemic in any moment of their pediatrics life and in the long time. It is necessary to realize an opportune identification in order to start management to decrease morbility and mortality cause cardiovascular disease. So it's necessary all pediatrician know the risk factors for hypercholesterolemia and look for them in every child undergoes clinical examination. 2433