Clinical significance of
the changes of TXA, and PGI, in asphyxiated newborns
Liu HC, Chang LW, Chen Y
Department of pediatrics, Tongji hospital, Tongji
Medical College, Huazhong University of Science and Technology, Wuhan,
China
Objective: To evaluate the level change of thromboxane A2 (TXA2)
and Prostacyclin (PGI2) in serum and cerebrospinal fluid (CSF)
in the asphyxiated newborn and explore relationships between the level of
them in CSF and hypoxic brain damage after neonatal asphyxia.
Methods: 36 full term newborns were divided into three
groups: 12 with severe hypoxic-ischamic encephalopathy (HIE), 13 with
mild-moderate HIE, 11 without HIE (control group). The levels of TXB2 (TXA2
metabolite) and 6-keto-PGF1α(PGI2 metabolite) in serum and CSF were
measured during 36-72 hours after birth.Determinations of their levels in
serum and CSF were performed by RIA and expressed as pg/ml(mean±SD).
Results: The levels of TXB2 and 6-keto-PGF1α in CFS in the severe HIE group(206.06±29.74,168.47±23.02,respectively)
were significantly higher than those of the mild-moderate HIE group(83.37±28.57,131.42±16.57,
respectively)(P<0.01) and the control group(41.77±21.58, 86.23±13.05,respectively)(P<0.01).
The levels of TXB2 and 6-keto-PGF1α in serum in the severe HIE group were also higher
than those of the mild-moderate HIE group and the control group(P<0.01),
but no significant difference was found between mild-moderate HIE group and
the control group(P>0.05).
Conclusion:
The
level changes of TXB2 a nd 6-keto-PGF1α in serum and CSF after neonatal asphyxia may
evaluate the severity of brain damage, and the level changes in CSF were
more sensitive than those in serum.