Text Box: PATIENT EVALUATION OF INJECTION PEN FOR TREATMENT WITH GROWTH HORMONE C COMPARISON BETWEEN TWO DEVICES
Noda H1, Ohnishi H1, Saitoh K1, Sato H2, Miyamoto S2, Sasaki N3
1Department of Pediatrics, Funabashi Central Hospital, Chiba, Japan
2Division of Endocrinology, Chiba Childrens Hospital, Chiba, Japan
3Department of Pediatrics, Saitama Medical School, Saitama, Japan

Objective: To improve compliance in growth hormone (GH) treatment, a convenient injection device is important. Patient convenience was evaluated and the result was compared between two devices based on a questionnaire.
Methods: Sixty-five and 30 children on GH therapy and using A and B devised pens respectively participated in this study. The main difference between the two pen devices was the preparation of GH before injection, in which A was to add a solution with syringe to a GH powder contained cartridge loaded in the pen whereas B was proceeded by two-chamber cartridge. The questionnaire was about the ease of handling the pen, particularly with regard to attaching the needle, preparation of GH, dose setting, air elimination before injection and injection. 
Results: No significant difference was found in patient convenience between the two devised pens, although the elimination of air before injection was a little more difficult in A than B. 
Conclusions: It is concluded that the use of injection pen in growth hormone treatment tends to be acceptable although with difference in some device.
2498