HANTAVIRUS
SURVEILANCE AT THE PEDIATRIC DEPARTMENT, SUMBER WARAS HOSPITAL, INDONESIA
Tatang K Samsi1,
Hansa Wulur1, Sugianto Djoharman1, Kevin R Porter2,
Ratna Tan2 and Herman Kosasih2
1 Pediatric
Department, Faculty of Medicine, Tarumanagara University, Indonesia and 2
NAMRU 2 Jakarta detachments, Indonesia
Objective: Dengue hemorrhagic fever (DHF) is an endemic
disease in Indonesia, whereas Hemorrhagic fever with renal syndrome (HFRS)
is endemic in East Asia. Serologic surveys for hantaanvirus (HTN) of
commensal rodents and healthy workers in harbour area of Jakarta revealed
positive sera. This study is carried out to investigate the prevalence of
HTN infection among hemorrhagic fever patients.
Subjects and methods: The subjects of the study were DHF
suspected patients admitted during the period of March 1999-October 1999.
RT-PCR dengue (DEN) test was performed on acute sera, IgM DEN using MRL
kit; IgM and IgG HTN using recombinant antigen from MRL and/or hantaan
cell-lysate antigen on acute and
convalescent sera.
Results: Of 48 subjects (24 female and 24 males, age range from
4 years-14 years) 6 were negative for DEN and HTN, 32 positive for DEN (1
Dengue Shock Syndrome), 4 positive for HTN and 6 positive for DEN and HTN.
HTN infection was detected in 20% of hemorrhagic fever patients. The
symptoms of hantaanvirus positive patients include fever, bleeding
manifestations and flu like illness but none with renal disorders.
Conclusion:
Although DHF is highly
endemic in Jakarta, HTN infection as an emerging disease in the region must
be considered as one of the etiologic agent in hemorrhagic fever.
Further study is needed
to evaluate the prevalence of HTN infection in severe cases of DHF
including Dengue shock syndrome.