URODYNAMIC STUDY IN FREE AUTOGENOUS PALMARIS LONGUS MUSCLE
TRANSPLANTATION IN RHESUS MONKEY WITH URINARY INCONTINENCE
Mo Jiacong,
Wang Wenwei
Department
of Pediatric Surgery, First Affiliated Hospital, Sun Yat-Sen University of
Medical Sciences, Guangzhou, China
Objective: Making
urodynamic investigations in free autogenous palmaris longus muscle
transplantation in experimented rhesus monkey with urinary incontinence due
to sphincteric deficiency for clinical treatment．
Methods: At the
second week after denervation, the palmaris longus muscle was transplanted
to the posterior urethra to strengthen the function of urethral sphincteric
muscle in monkeys with urinary incontinence. The micturating condition and
the urodynamics were evaluated at the different stages after
transplantation.
Results: In 20
experimented monkeys with urinary incontinence ,UFL was (0.94 ± 0.07 ) cm in male or
(0.82±0.130)cm in female both
lower than normal (p<0.001);but raised to (3.97±0.18)cm in male or to (3.37±0.10)cm in female in the fifth month after
transplantation both higher than normal (p<0.05). And UMCP was (4.17±0.31)mmHg lower than
normal (p<0.001) , but raised to (59.70±1.03) mmHg in the fifth month after
transplantation near to normal (p>0.05). And in urethral intrinsic
sphincter EMG, the pulse amplitude was (0.052±0.031)mV, the pulse frequency was (3.71±0.16)/min; in urethral
external sphincter EMG, the pulse amplitude was (0.095±0.025) mV, the pulse frequency was (61.75±3.12)/min ,they all lower
than normal (p<0.001),and also lower than normal (p<0.001) in the
fifth month after transplantation. Within the fifth month after
transplantation the improvement was demonstrated by micturating condition. Except
one female monkey had urinary-leaking occasionally when she moved or
jumped, the others had been cured.
Conclusions: The
procedure could be effective in treating the urinary incontinence due to
sphincteric deficiency. And urodynamic investigation is a useful way for evaluation the function
of lower urinary tract.