THE EXPRESSION OF
NUCLEAR TRANSCRIPTION FACTOR C-FOS AND C-JUN IN CEREBRAL HYPOXIA-ISCHEMIA
IN NEW BORN RAT
Zeng Zhen, Zhangxiao, Chenchanghui, et al.
Department of Pediatrics, Sichuan Province People’s
Hospital, Chengdu, China
Objective: To
investigate the relationship between the expression of c-fos as well as c-jun
and cerebral hypoxia-ischemia in newborn rats.
Methods: 18
Wistar rats made the model of hypoxia -ischemia in experiment were divided
into two groups, the group of experiment used 12 rats. The control group
were 6 rats. The Rt-PCR and blots hybridization were used in experiment.
Results:
There were significance variation between the expression of c-fos and c-jun
in different time， (P＜0.01, which the groups of
72 hours and 92 hours were higher than the groups of 24 hour＝, in different aeres (P＜0.01, which the areas of
CA3 of dental grays and basal ganglia were bigger than the areas of
somatosenssr.
Conclusin: These results indicated that the in
expression genes c-fos, c-jun could be induced by cerebral hyposia-ischemia
and the genes may be one of the gene induced neuron cell apoptosis.