DIPYRIDAMOLE AND ADENOSIN INTERVENES TO PULMONARY
FIBROSIS IN MICE
Pan JH, Lou WL, Chen LJ,et al.
Affiliated Hospital
of Bengbu Medical College, Bengbu, Anhui, China
Objective: To evaluate the effect of dipyridamole
(DPM), adenosine (ADO) intervening to pulmonary interstitial fibrosis in
mice.
Methods: 100 mice, which were injected bleomycin (BLM,
8.5 mg/Kg) by bronchus, were divided into control group, treated groups by
DPM, ADO, DPM and TH. Pulmonary pathologic observations were made by light
and electron microscope separately from 4 to 30 days.
Results: Alveoli epithelial cell appeared
necrosis, lung tissue hypoxia and interstitial fibrosis were found in the
group of BLM after 10 day. The necrotic alveolar epithelial cells and
fibroblasts were fewer, lung tissue hypoxia milder, the number and
phagocytic function of macrophage increased in the groups of DPM and ADO.
In the group of TH, necrotic alveolar epithelial cell increased, the lung
tissue was ischemia, the developing process from monocyte to macrophage in
pulmonary interstitial was slower.
Conclusion: DPM and ADO can improve
microcirculation, promote macrophage development, reconstruct alveolar
spaces and inhibite fibroblast hyperplasia