ASSESSED LEFT VENTRICULAR FUNCTION IN CHILDREN WITH MYOCARDITIS BY
DOBUTAMINE STRESS ECHOCARDIOGRAPHY
He Xiyu, Luo Fenping, Jian Wenhao
Department
of Pediatrics, Beijing Military General Hospital, Beijing, China
Objective: Virus myocarditis in children usually cause some
degrees damage at cardiac function and structure. Dobutamine stress
echocardiography (DSE) as an alternative noninvasive tests has become
wildly accepted in adult with coronary heart disease. However there have
been few reports about use of DSE for the detection of left ventricular
dysfunction and evaluation the cardiac reserve in children with virus
myocarditis.
Method:
20 patients (9 male and 11 female, range 4 to 14 years, median age 8 years)
were submitted the study subject, 9 healthy children (5 male and 4 female,
range 6 to 13 years, median age 11 years) as the control. Dobutamine was
infused at the rate of 2.5 to 5.10.15 μg/kg/min
and echocardiographic measurements were obtained at the rest and the end of
each stage. The test could be completed in 100% of the subjects without
major complications.
Result:
After the pharmacological stress ,the myocarditis group ejection fraction(EF)(%)decreased
to 50±18 from 59±18.2,left ventricular
fractional shortening (FS%) decreased to 30±15 from 46±17,
left ventricular posterior wall thickness (PWT%) decreased to 54.7±20 from 63.3±19.1 and inter ventricular
wall thickness(IVWT%) decreased to 61.3±18
from 67.1±20.5,but at healthy
children group. EF increased to 79.7±5.6
from 72.1±8. FS to 41.1±8.1 from 48.0±3.8, PWT to 64.4±21 from 51.9±19, IVWT to 82.4±14 from 76.3±28.
Conclusions:
DSE might be used to determined cardiac dysfunction in children with
myocarditis and evaluate serious degress and prognoise of the illness. It
will be helpful to assess the cardiac reserve.