HBV TRANSMISSION FROM MOTHERS TO THEIR BABIES AND
INFLUENCE OF HBV INFECTION TO MOTHER AND THEIR BABY HEALTH CONDITION
Dinh Thi Binh,Vu Bang Dinh, Nguyen Anh Tuan,
Nguyen Kim Nu Hieu
Tran Hung Dao General Hospital, Hanoi, Vietnam
Objective of this study were to find out
situation of HBV infection in pregnant women and transmission from mothers
to their babies in Hanoi, Vietnam. The role of HbeAg and Anti-Hbe in HBV transmission,
mothers and their babies heath condition were also observed in research
group.
Subject: 1564 pregnant women.
Methods: SP-RIA technique, kit from CIAE were used for detection
of HBV marker.
Results: 10.6% of pregnant women were reactive for HbsAg, 27%
were reactive for HbsAg and HbeAg, 58,2% were reactive for HbsAg and Anti-Hbe,
After 5 years follow-up, in group of patients with HbsAg and HbeAg
positive, 100% were reactive for HbsAg and 88.2% had increase of SGOT,
SGPT; while in group of patients with HbsAg and Anti-Hbe positive only
90.4% were reactive for HbsAg and 24.1% had increase of SGOT, SGPT.
Some manifestation such as
overtime pregnancy , intervention at birth, too much and long bleeding…
were higher in the group of the pregnant women with HbsAg positive than
group of normal pregnant women (P<0.05) especially higher in pregnant
women with HbeAg positive (P<0.001).
After the birth, manifestation
of liver function disorder were increased, especially in group of pregnant
women who have HbsAg and HbeAg positive to compare with group who have only
HbsAg positive or HBsAg and Anti-HBe positive(P<0.001).
Through the examination of HbsAg in umbilical
blood or thd babies, we realised that 23.6% of babies who were born from
mothers with HBsAg(+) have positive result, while 66.7% of babies who were
born from mothers with HBsAg and HBeAg(+) have positive result, 7.6% if
babies who were born from mothers with HbsAg and Anti-Hbe(+) were reactive
for HBsAg (P<0.001). After one year follow-up, in the group of babies
with HbeAg positive, 87.5% were reactive for HbsAg; while in the group of
balies with Anti- Hbe positive,
only 50% were reactive for HbsAg, After 5 years follow-up no more cases had
seroconversion.
One years after the birth,
46.7% of babies with HBsAg(+)had liver function disorder
such as increase of SGOT and SGPT, meanwhile there were only 2/30 babies
who have clinical picture of hepatitis. After 5 years follow-up only 12-20%
of babies with HbsAg positive had slight increase of SGOT, SGPT.
Conclusion: HBV transmission from mothers to their babies were very
important route, especially in mothers who have HBeAg positive.